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Caribbean L 26 ife, OCTOBER 25-31, 2019 BQ
Brooklyn College Biology Professor, Anjana Saxena. David Rozenblyum
Brooklyn College professor
fights cancer by awakening
immune system
By Nelson A. King
A Brooklyn College professor is
fighting cancer by awakening the
immune system, according to Brooklyn
College (BC) News.
It said that Dr. Anjana Saxena, an
associate professor in the Biology
Department, actively participated in
this “game-changing research,” led
by New York University (NYU) scientists.
Their findings are published in
“Nature and Cancer Discovery,” BC
News said.
“Awakening our immune systems
to combat cancer is an exponentially
growing research field,” Saxena, who
has authored or co-authored dozens
of articles on cancer research, told
BC News.
“The tumor microenvironment
is often rich in immune-suppressive
cells, a characteristic feature of
pancreatic adenocarcinoma (PDA),”
added Saxena, who teaches a course
she developed called Cancer Biology,
and also focuses on microbes and
cancer in her other classes. “Weakened
immune response is the major
obstacle in targeted immunotherapy
against PDA.”
BC News said Saxena, who pursued
undergraduate and doctoral studies
at the University of Mumbai, India,
collaborated with researchers at NYU
“and found a promising solution to
the weakening of the immune system
as a result of cancer.”
“We found earlier that bacteria
reaching the pancreas are the culprit,”
Saxena said. “It not only debilitates
the immune system’s fight
against cancer but also speeds up its
progression.
“We now report in ‘Nature’ that
fungi (mycobiome) coming from gut
can also be deposited in pancreas
to aggravate pancreatic cancer,” she
added.
To find a solution, BC News said
the researchers used a mouse model
to show that when a combination of
antibiotics reduce either bacterial or
fungal loads in cancerous pancreas,
the immune system is “kind of
rebooted in the right direction” to
provide protection against PDA invasion
(metastasis/progression).”
Although not yet close to a cure,
BC News said these discoveries are
remarkably positive steps in the quest
to contain this disease.
“Identifying unique microbial
(both microbiome and mycobiome)
signatures for pancreatic patients has
great potential for a selective antibiotic
regimen for this deadly cancer,”
Saxena said.
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